Getryl ( Glimepriride ).. Tablets 1 mg , 2mg .. pharmacyteach.com

             Getryl ( Glimepriride ) 

                         Tablets 1 mg , 2mg, 3mg,and 4mg :-

Description :-

         Getryl  ( Glimepriride ) is an oral blood glucose lowering drug of the sulfonylurea class . 

The molecular formula is C24 H34N5O5S 

 and 

the structural formula is ; 

Getryl ( Glimepriride )..Tablets 1 mg ,2mg . pharmacyteach.com

Clinical Pharmacology :-

 

Mechanism of action :

The essential instrument of activity of glimepiride appears to be reliant upon invigorating the arrival of insulin from working pancreatic beta cells .

pharmacokinetics and pharmacodynamics

In addition, extrapancreatic effects  ( e.g. reduction of basal hepatic glucose production and increased peripheral tissue sensitivity to insulin and glucose uptake ) may also play role in the activity of glimepiride.

 Therapeutic indications

Getryl (glimepiride) is shown as an assistant to counting calories and exercise to bring down the blood glucose in patients with noninsulin-subordinate (type 2) diabetes mellitus (NIDDM) whose hyperglycemia can't be controlled by diet and exercise alone:

GETRYL (Glimepiride) may be used concomitantly with metformin when diet, exercise, 

and GETRYL (Glimepiride) or metformin alone do not result in adequate glycemic control:  

GETRYL (Glimepiride) is additionally shown for use in the mix with insulin to bring down blood glucose in patients whose hyperglycemia can't be constrained by diet and exercise related to by diet and exercise. 

 Dosage & administration :-

In starting treatment for noninsulin - subordinate diabetes, diet and exercise ought to be stressed as the essential type of treatment.

There is no fixed measurement routine for the administration of DM with GETRYL ( Glimepiride ) or the other hypoglycaemic specialist.

The patient's fasting blood glucose and HbA1c should be estimated occasionally to decide the base viable portion for the patient.

Pharmacokinetics:- 

            After oral administration Glimepiride is entirely absorbed from the gastrointestinal tract. the oral bioavailability is approximately 100%. Peak plasma concentration occurs in 2-3 hours.  99% of the drug is bound to proteins of plasma.

Glimepiride is totally utilized by oxidative biotransformation into two fundamental metabolites, a hydroxy subordinate, and a carboxy subsidiary.

The elimination half-life (t1/2) after multiple dosages is about 5 hours. 

Adverse effects : 

 Glimepiride is generally well tolerated. Anyway following are the adverse effects during treatment with glimepiride.

1. Hypoglycemia; 

         Hypoglycemia is a common potential risk with all sulfonylurea. 

2. Visual reaction; 

           There may be temporary visual impairment  (e.g . Change in accommodation and /or blurred vision ) due to the change in blood glucose levels, especially at the start of treatment. 

3. Electrolyte disturbance; 

          In isolated cases, hyponatremia has been reported in patients receiving glimepiride and another sulfonylurea, most often in patients who are on other medications or have medical conditions known to cause hyponatremia or to increased release of antidiuretic hormones

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